Chicken Bubble Biscuit Casserole

Save this article on:

Creamy, cheesy, and irresistibly comforting — the Chicken Bubble Biscuit Casserole is the kind of dish that turns an ordinary dinner into a cozy, satisfying experience. Picture tender shreds of seasoned chicken nestled in a rich, savory sauce, all baked together with golden, fluffy biscuit bites that bubble up as they bake. Every spoonful is a dreamy bite of warmth, flavor, and cheesy bliss.

This dish is a hit for weeknight dinners, potlucks, or when you’re craving a one-dish meal that feels like a warm hug. It’s quick to throw together with simple pantry staples and rotisserie chicken, yet the end result tastes like you spent hours crafting a homestyle comfort meal. Whether you’re feeding picky eaters or hungry guests, this casserole never disappoints.

Why You’ll Love This Chicken Bubble Biscuit Casserole

• Quick & Easy: Uses pre-cooked chicken and refrigerated biscuits to save time.
• Family Favorite: Creamy, cheesy, and baked to perfection — even picky eaters love it.
• Perfect for Leftovers: Tastes just as good the next day.
• Customizable: Add veggies, switch cheeses, or use different seasonings to make it your own.

Preparation Phase & Tools to Use

To make this casserole come together smoothly, gather these essential tools:

• Mixing Bowls: Ideal for combining the chicken, sauce, and seasonings evenly.
• Measuring Cups & Spoons: For accurate proportions, especially with creamy sauces.
• Baking Dish (9×13-inch): Provides enough space for the biscuits to rise and bake evenly.
• Spatula or Spoon: Useful for spreading and mixing.
• Can Opener: If using canned soup or refrigerated biscuit dough.
• Oven Mitts: Safety first when pulling out hot, cheesy goodness from the oven!

Each tool ensures you move efficiently from prep to bake, without scrambling for what you need mid-recipe.

Preparation Tips

To get the most delicious results, make sure your chicken is well-seasoned before mixing into the casserole. If you’re using rotisserie chicken, give it a rough chop or shred for a better texture blend. Cut the biscuit dough into small bite-sized pieces – this helps them cook evenly and soak up more of the creamy sauce. For an extra pop of flavor, sprinkle a little garlic powder or onion powder into the mix. And don’t forget to preheat the oven fully so the biscuits rise properly and the top gets beautifully golden and cheesy.

---

Ingredients for this Chicken Bubble Biscuit Casserole

• 3 cups cooked chicken, shredded (rotisserie chicken works perfectly)
• 1 can (10.5 oz) cream of chicken soup
• 1 cup sour cream
• 1/2 cup milk
• 2 cups shredded cheddar cheese (divided)
• 1/2 teaspoon garlic powder
• 1/2 teaspoon onion powder
• Salt and pepper to taste
• 1 can refrigerated biscuit dough (8-count, cut into quarters)
• 1 tablespoon melted butter (optional, for brushing the top)
• Fresh parsley (optional, for garnish)

---

Step 1: Preheat the Oven

Preheat your oven to 350°F (175°C). Greasing a 9×13-inch baking dish will prevent sticking and make cleanup easier.

---

Step 2: Prepare the Chicken Mixture

In a large mixing bowl, combine the shredded chicken, cream of chicken soup, sour cream, milk, 1 cup of shredded cheddar cheese, garlic powder, onion powder, salt, and pepper. Mix thoroughly until the sauce is creamy and evenly coats the chicken.

---

Step 3: Add the Biscuits

Cut the biscuit dough into quarters and gently fold them into the chicken mixture. Make sure the biscuit pieces are fully coated but not overly squished, so they can puff up while baking.

---

Step 4: Transfer to Baking Dish

Pour the entire mixture into your greased baking dish. Spread it evenly using a spatula, ensuring biscuit chunks are distributed throughout for even baking.

---

Step 5: Top with Cheese

Sprinkle the remaining 1 cup of shredded cheddar cheese evenly over the top of the casserole. If desired, brush the top lightly with melted butter for extra golden color and flavor.

---

Step 6: Bake

Place the dish in the preheated oven and bake for 35 to 40 minutes, or until the biscuits are cooked through and the top is bubbly and golden brown. Check the center with a toothpick to make sure the biscuit dough is fully cooked.

---

Step 7: Cool and Garnish

Let the casserole rest for about 5–10 minutes after baking to allow it to set. Garnish with chopped fresh parsley before serving for a pop of color and freshness.

---

Notes

This casserole is very forgiving and flexible, making it a go-to for busy nights or meal prepping. Using rotisserie chicken significantly cuts down prep time without compromising on flavor. For a richer taste, you can substitute the cream of chicken soup with a homemade roux-based sauce, though the canned version keeps it ultra-simple. Adding vegetables like peas, broccoli, or diced bell peppers can make it a more complete meal. Just make sure they are pre-cooked or thawed before adding to the mix.

---

Watch Out for These Mistakes While Cooking

• Overmixing the biscuits: Stir the biscuit pieces in gently to avoid making the dough tough or unevenly cooked.
• Not spacing biscuits evenly: Crowding biscuit pieces in one area can cause underbaking; distribute them throughout the dish.
• Undercooking: Check the center for doneness; raw dough in the middle is common if baked too short.
• Skipping the rest time: Letting the casserole sit for a few minutes after baking helps everything set and makes serving cleaner.
• Using too much liquid: Stick to the recommended amounts; too much milk or soup can cause a soggy texture.

---

Storage Instructions

Allow the casserole to cool completely before storing. Cover tightly with plastic wrap or transfer to an airtight container. It will keep in the refrigerator for up to 4 days. For longer storage, freeze individual portions wrapped in foil and placed in a freezer bag for up to 2 months. Reheat in the oven or microwave until hot throughout, adding a splash of milk if needed to restore creaminess.

---

Estimated Nutrition (Per Serving – Approx. 6 servings)

• Calories: 480
• Protein: 28g
• Fat: 30g
• Saturated Fat: 14g
• Carbohydrates: 27g
• Sugar: 3g
• Fiber: 1g
• Sodium: 890mg
• Cholesterol: 105mg

---

Frequently Asked Questions

Can I use canned chicken instead of rotisserie chicken?

Yes, you can use canned chicken in a pinch. Just be sure to drain it well and break it into smaller pieces.

Can I make this casserole ahead of time?

Absolutely. Assemble it in advance, cover, and refrigerate for up to 24 hours before baking.

Can I add vegetables to the casserole?

Yes! Peas, carrots, broccoli, or corn are great additions. Cook or thaw them before adding.

What if I don’t have cream of chicken soup?

You can substitute it with cream of mushroom or cream of celery, or make a simple roux-based sauce with butter, flour, and chicken broth.

How do I know when the casserole is fully cooked?

The biscuits should be puffed and golden. Insert a toothpick in the center — if it comes out clean (no raw dough), it’s ready.

Can I use homemade biscuit dough?

Definitely. Just cut your dough into 1-inch pieces and follow the same instructions.

Is this recipe freezer-friendly?

Yes. Freeze fully baked and cooled portions. Reheat in the oven at 350°F until warmed through.

Can I use a different cheese?

Cheddar is classic, but you can swap with mozzarella, Monterey Jack, or a blend for different flavors.

---

Conclusion

Chicken Bubble Biscuit Casserole is the ultimate comfort food with minimal effort. It’s creamy, cheesy, and packed with hearty flavor in every bite. Whether you’re feeding a hungry family or looking for a dish to impress at your next potluck, this casserole is a dependable, delicious solution. Best of all, it’s highly adaptable, making it a perfect fit for your weekly dinner rotation or freezer meal stash.

---

Print