Chicken Alfredo Lasagna

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I’ve always had a soft spot for creamy, cheesy comfort food, and Chicken Alfredo Lasagna checks every single box. The first time I made it, I was looking to shake up my usual lasagna routine and skip the tomato sauce entirely. What came out of the oven was golden, bubbling, and almost too perfect to cut into—until I took that first bite. Tender chicken, rich Alfredo sauce, and layers of pasta and melted cheese created a dish that instantly became a family favorite.

This lasagna is a warm hug on a plate. It’s the kind of meal you make when you want to impress guests or simply treat yourself to something extra cozy. I love how the white sauce seeps into every layer, and the way fresh herbs lift the richness just enough to keep you coming back for seconds (and thirds).

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Why You’ll Love This Chicken Alfredo Lasagna

Chicken Alfredo Lasagna is the perfect blend of creamy, savory, and satisfying. It’s rich but balanced, indulgent without being over-the-top. The Alfredo sauce adds a luxurious texture, while the shredded chicken provides hearty substance. Unlike traditional red-sauce lasagnas, this version feels a bit more elegant—yet it’s still straightforward to make. Whether you’re planning a dinner party or a quiet night in, this recipe is always a winner.

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What Kind of Chicken Should I Use for Chicken Alfredo Lasagna?

You have a few good choices when it comes to the chicken in this lasagna. I usually go with shredded rotisserie chicken because it saves time and adds great flavor without extra work. However, if you prefer a homemade touch, you can poach or roast chicken breasts or thighs and shred them yourself. Thigh meat will give you more richness and moisture, while breast meat keeps things leaner. Just make sure the chicken is cooked and seasoned before it goes into the layers—it makes all the difference.

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Options for Substitutions

One of the things I love about this dish is how adaptable it is. If you’re not a fan of chicken, try turkey or even a hearty vegetable like roasted mushrooms or spinach for a vegetarian twist. For the sauce, you can use store-bought Alfredo in a pinch, though homemade is always best for flavor. Not into lasagna noodles? Try oven-ready sheets to skip a step or substitute with gluten-free pasta to suit dietary needs. As for cheese, mozzarella is classic, but feel free to blend in provolone or gouda for extra melt and depth.

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Ingredients for This Chicken Alfredo Lasagna

Lasagna noodles
These are the foundation of the dish, creating structure and layers to hold all the creamy filling. You can use regular, oven-ready, or fresh pasta sheets depending on your preference.

Cooked shredded chicken
Tender, juicy chicken adds protein and heartiness to the lasagna. Rotisserie chicken works beautifully and adds a boost of flavor with minimal effort.

Butter
Used to start the Alfredo sauce, it brings richness and depth right from the beginning.

Garlic
A few cloves go a long way in building savory flavor in the sauce—it’s an essential backbone.

Flour
Helps thicken the Alfredo sauce and gives it a luscious, velvety consistency.

Milk and heavy cream
The combination of the two gives the sauce both lightness and richness, creating that signature creamy texture.

Parmesan cheese
Sharp and nutty, this cheese is key to a flavorful Alfredo sauce. It also adds saltiness and helps the sauce cling to the layers.

Mozzarella cheese
Provides that gooey, melty, cheesy goodness we all expect in lasagna. It browns beautifully on top for that golden crust.

Ricotta cheese
Smooth and creamy, ricotta adds a luxurious layer and keeps the texture light between the noodles.

Fresh parsley or Italian herbs
A sprinkle of herbs brightens up the richness and adds a pop of color and freshness to the final dish.

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Step 1: Prepare the Alfredo Sauce

Start by melting butter in a large saucepan over medium heat. Add minced garlic and cook until fragrant. Stir in the flour and whisk constantly for about 1 minute to create a roux. Slowly pour in the milk and heavy cream, whisking to remove any lumps. Let it simmer until slightly thickened, then stir in grated Parmesan cheese until melted and smooth. Season with salt and pepper to taste.

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Step 2: Cook the Lasagna Noodles

If you’re not using oven-ready noodles, bring a large pot of salted water to a boil. Cook the lasagna noodles until al dente, according to package directions. Drain and lay them flat on a clean surface or parchment paper to prevent sticking.

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Step 3: Mix the Ricotta Filling

In a mixing bowl, combine ricotta cheese with chopped parsley or your favorite Italian herbs. Add a pinch of salt and mix well. This herbaceous blend adds a creamy, flavorful layer to each bite.

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Step 4: Assemble the Lasagna

Spread a thin layer of Alfredo sauce on the bottom of a baking dish. Layer with noodles, a portion of the ricotta mixture, shredded chicken, a handful of mozzarella, and more Alfredo sauce. Repeat the layers until all ingredients are used, finishing with a generous layer of sauce and mozzarella on top.

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Step 5: Bake

Cover the lasagna with foil and bake in a preheated oven at 375°F (190°C) for 25 minutes. Remove the foil and continue baking for another 15–20 minutes, or until the top is golden and bubbling. Let it rest for 10–15 minutes before slicing to help everything set.

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How Long to Cook the Chicken Alfredo Lasagna

You’ll want to bake the lasagna at 375°F (190°C) for a total of about 40–45 minutes. The first 25 minutes should be covered with foil to help the layers heat through and meld together without drying out. Then, uncover it for the last 15–20 minutes so the cheese on top can get beautifully golden and bubbly. Letting it rest for at least 10 minutes before slicing ensures clean, firm layers.

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Tips for Perfect Chicken Alfredo Lasagna

• Use quality cheese: Freshly grated Parmesan and mozzarella melt better and offer more flavor than pre-shredded varieties.
• Season each layer lightly: A pinch of salt and a sprinkle of herbs in the ricotta and sauce keeps the flavor balanced throughout.
• Avoid overly watery sauce: Let your Alfredo simmer until it’s noticeably thick—it will thin slightly during baking.
• Cook noodles al dente: They’ll absorb some of the sauce as the lasagna bakes, so slightly undercooked noodles are perfect.
• Let it rest: It may be tempting to dig right in, but a short rest lets the lasagna hold its shape when served.

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Watch Out for These Mistakes While Cooking

• Skipping the sauce thickening step: If the Alfredo is too thin, the lasagna will be runny and won’t hold layers well.
• Overloading the layers: Too much filling can make it collapse or bake unevenly—balance is key.
• Using watery chicken: If your chicken is overly moist (especially from poaching), pat it dry before layering to avoid a soggy texture.
• Not seasoning the ricotta: This layer needs flavor too—add herbs, salt, and maybe a bit of garlic powder.
• Forgetting to cover during the first bake: This traps in moisture and helps the lasagna cook evenly.

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What to Serve With Chicken Alfredo Lasagna?

Caesar Salad

The crisp romaine, crunchy croutons, and creamy dressing contrast the richness of the lasagna beautifully.

Garlic Bread

A crunchy-on-the-outside, buttery-on-the-inside slice of garlic bread is a must for mopping up extra sauce.

Steamed Broccoli

A light and healthy side that adds color and keeps the plate balanced.

Roasted Vegetables

Carrots, zucchini, and bell peppers roasted with olive oil and herbs offer a perfect earthy counterpoint.

White Wine

A glass of Chardonnay or Pinot Grigio complements the creamy sauce without overpowering it.

Cucumber Tomato Salad

Fresh, cool, and lightly tangy—a refreshing palate cleanser.

Lemon Asparagus

Bright, citrusy asparagus pairs wonderfully with the creamy layers.

Light Fruit Salad

End the meal on a refreshing note with berries and melon tossed in a light mint syrup.

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Storage Instructions

Chicken Alfredo Lasagna stores beautifully, making it ideal for leftovers or meal prep. Once cooled, wrap the dish tightly with foil or transfer individual portions into airtight containers. It will keep in the refrigerator for up to 4 days. For longer storage, freeze in freezer-safe containers for up to 3 months.

To reheat, warm it in a 350°F (175°C) oven until heated through (about 20–25 minutes if refrigerated, longer if frozen). Add a splash of milk or cream before reheating to restore creaminess if the sauce has thickened too much.

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Estimated Nutrition

Please note these are general estimates per serving (based on 8 servings total):

• Calories: ~620
• Protein: ~36g
• Fat: ~38g
• Saturated Fat: ~20g
• Carbohydrates: ~35g
• Fiber: ~2g
• Sugar: ~4g
• Cholesterol: ~130mg
• Sodium: ~780mg

This dish is rich and filling, so a modest portion goes a long way. Balance it out with light sides for a well-rounded meal.

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Frequently Asked Questions

What’s the best type of noodle for Chicken Alfredo Lasagna?

Traditional lasagna noodles or oven-ready noodles both work. Just ensure they’re cooked al dente if boiling first.

Can I make this lasagna ahead of time?

Yes! You can assemble it up to 24 hours in advance and refrigerate until ready to bake. Add a few extra minutes to the baking time if starting cold.

Can I freeze Chicken Alfredo Lasagna?

Absolutely. Freeze it before or after baking. Just make sure it’s tightly wrapped and use within 3 months for best quality.

Is it okay to use store-bought Alfredo sauce?

Yes, though homemade gives a richer flavor. If using store-bought, choose a high-quality version and consider enhancing it with fresh garlic or Parmesan.

How do I prevent my lasagna from being watery?

Use thick Alfredo sauce and dry, shredded chicken. Avoid watery vegetables or overcooked noodles.

What cheese substitutes can I use?

Feel free to swap mozzarella with provolone or fontina, and ricotta with cottage cheese for a slightly different texture.

How do I know when it’s done baking?

It should be hot and bubbling around the edges, with a golden, lightly browned top. A thermometer inserted in the center should read at least 165°F.

Can I make this dish gluten-free?

Yes! Use gluten-free lasagna noodles and ensure your Alfredo sauce is thickened with a gluten-free flour like cornstarch or rice flour.

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Conclusion

Chicken Alfredo Lasagna brings together everything I love about comfort food—creamy sauce, melty cheese, and satisfying layers. It’s elegant enough for guests, yet easy enough for a weeknight dinner. Once you master the simple steps, you’ll find yourself coming back to this dish again and again. Whether you’re serving it with crisp salad, garlic bread, or just a glass of wine, it’s guaranteed to leave everyone at the table happy and full.

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