Bubble Up Biscuit Pizza Casserole

Golden-brown biscuits baked into gooey layers of melted mozzarella, tangy pizza sauce, and crispy pepperoni—this Bubble Up Biscuit Pizza Casserole is a comfort food dream. Each bite delivers that irresistible cheesy-pizza flavor with the fluffy, buttery bite of biscuits “bubbling up” beneath the toppings. It’s the kind of dish that turns any ordinary dinner night into a pizza party, without rolling out any dough.

Perfect for busy weeknights, weekend potlucks, or feeding hungry kids after school, this recipe is quick, filling, and requires minimal prep. Everything comes together in one casserole dish, so cleanup is a breeze. If you’re craving a fun twist on classic pizza or looking for easy dinner ideas that feel special, this bubble-up bake will earn a permanent spot in your recipe rotation.

Why You’ll Love This Bubble Up Biscuit Pizza Casserole

• Effortless and Fast: No kneading, no dough-making—just pop open a can of biscuits.
• Kid-Approved: It’s pizza in casserole form—what’s not to love?
• Customizable: Add your favorite pizza toppings—mushrooms, olives, sausage—to make it your own.
• One-Dish Meal: Easy assembly and even easier cleanup.

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Preparation Phase & Tools to Use

To make this casserole seamlessly, gather these kitchen essentials:

• 9×13-inch baking dish: Perfect size for allowing the biscuits to rise and “bubble up”.
• Kitchen shears or a knife: For quickly cutting the biscuits into quarters.
• Mixing bowl: To coat the biscuit pieces evenly with sauce and cheese.
• Rubber spatula: Helps mix without sticking and is gentle on the dough.
• Oven mitts: For safety while pulling that hot, cheesy goodness out of the oven.

Each of these tools plays a small but vital role in making prep efficient and the bake successful.

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Preparation Tips

Cut the biscuits into uniform pieces so they cook evenly and rise together. Toss the biscuit pieces thoroughly with the sauce and half the cheese before placing them into the baking dish. This ensures that every bite has flavor infused throughout, not just on top. Use pre-shredded cheese to save time, or shred it fresh for better melt quality. Don’t overload the top with too many toppings—too much moisture can make the biscuits soggy underneath. Finally, let it rest a few minutes after baking; the bubbling sauce settles, and the pieces hold together better when serving.

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Ingredients for this Bubble Up Biscuit Pizza Casserole

• 1 can (16.3 oz) refrigerated biscuit dough (like Pillsbury Grands, 8-count)
• 1 1/2 cups pizza sauce (store-bought or homemade)
• 2 cups shredded mozzarella cheese
• 30–40 slices of pepperoni (adjust to your preference)
• 1 tablespoon olive oil (for greasing the dish)
• 1/2 teaspoon Italian seasoning (optional, for added flavor)
• 1/4 teaspoon garlic powder (optional)
• Fresh chopped parsley or basil (for garnish)
• Optional toppings: sliced mushrooms, black olives, bell peppers, cooked sausage

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Step 1: Preheat the Oven

Set your oven to 350°F (175°C). This ensures it’s hot and ready to go once your casserole is assembled.

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Step 2: Prepare the Baking Dish

Lightly grease a 9×13-inch baking dish with olive oil or nonstick spray. This prevents sticking and makes for easier serving and cleanup.

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Step 3: Cut the Biscuits

Open the can of biscuit dough and cut each biscuit into 4 smaller pieces. This helps them cook through and rise evenly throughout the dish.

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Step 4: Mix the Base

In a large bowl, combine the biscuit pieces, pizza sauce, half of the shredded mozzarella cheese, garlic powder, and Italian seasoning. Stir gently to coat all the pieces evenly without tearing the dough.

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Step 5: Assemble the Casserole

Pour the biscuit mixture into the greased baking dish and spread it out evenly. Top with the remaining mozzarella cheese and layer the pepperoni slices on top. Add any optional toppings at this stage.

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Step 6: Bake

Place the dish in the preheated oven and bake for 30–35 minutes, or until the biscuits have puffed up and the top is golden and bubbly. Keep an eye on the center to make sure the dough is fully cooked—if needed, loosely cover with foil in the last 10 minutes to prevent over-browning.

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Step 7: Cool Slightly and Serve

Let the casserole rest for 5–10 minutes after baking. This allows the sauce to thicken slightly and makes it easier to cut clean slices. Garnish with fresh herbs for a pop of color and freshness before serving.

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Notes

This casserole is incredibly forgiving and adaptable. You can make it your own by changing the sauce (try barbecue or Alfredo for a twist) or using different cheeses like provolone, cheddar, or a spicy pepper jack. It’s also great for using up leftovers—toss in chopped veggies, cooked meats, or whatever pizza toppings you love. Just be cautious not to overload the dough, which can prevent it from rising properly.

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Watch Out for These Mistakes While Cooking

• Overcrowding with toppings: Too many wet or heavy ingredients can make the bottom soggy.
• Undercooking the center: Check the middle with a fork to ensure biscuits are fully baked; if not, tent with foil and bake a little longer.
• Skipping the mixing step: Don’t just layer the sauce on top—mixing it with the biscuits ensures even flavor and rise.
• Using too much sauce: It can drown the biscuits and prevent that fluffy texture. Stick to about 1 1/2 cups.
• Cutting while hot: Letting it rest after baking makes it easier to serve and avoids a runny mess.

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Storage Instructions

Allow leftovers to cool completely before storing. Transfer to an airtight container and refrigerate for up to 3 days. To reheat, use the oven or toaster oven at 350°F for 10–15 minutes to maintain crispness. While microwaving works in a pinch, it may result in a softer texture. For freezing, wrap individual portions tightly in plastic wrap and foil; freeze for up to 2 months. Thaw overnight in the fridge before reheating.

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Estimated Nutrition

(Per serving, based on 8 servings)

• Calories: ~380 kcal
• Protein: 14g
• Carbohydrates: 30g
• Sugars: 5g
• Fat: 22g
• Saturated Fat: 9g
• Unsaturated Fat: 10g
• Cholesterol: 45mg
• Sodium: 830mg
• Fiber: 1g

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Frequently Asked Questions

How do I know the biscuits are cooked all the way through?

Check the center with a toothpick or fork. If it comes out doughy, bake for an additional 5–10 minutes, covering loosely with foil to prevent burning.

Can I use homemade biscuit dough?

Absolutely! Just make sure the dough is cut into small, uniform pieces for even cooking.

What other toppings can I use?

Feel free to add mushrooms, cooked sausage, onions, olives, jalapeños, or even pineapple. Just avoid overly wet ingredients.

Can I make this ahead of time?

Yes, you can assemble the dish a few hours ahead and refrigerate it. Let it sit at room temperature for 20 minutes before baking.

Can I make it vegetarian?

Yes! Just skip the pepperoni or substitute it with vegetarian slices and load up on veggies.

Can I double the recipe?

Yes, but use two 9×13 dishes or one larger dish and extend baking time slightly. Check the center for doneness.

What’s the best cheese to use?

Mozzarella is classic, but mixing in provolone, cheddar, or Monterey Jack adds great flavor and meltability.

Is this freezer-friendly?

Yes! Freeze in portions for quick meals later. Thaw in the fridge overnight and reheat in the oven.

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Conclusion

Bubble Up Biscuit Pizza Casserole delivers all the fun and flavor of pizza night with none of the hassle. It’s hearty, cheesy, and endlessly customizable, making it perfect for family dinners, casual gatherings, or satisfying late-night cravings. Whether you’re a beginner in the kitchen or a seasoned cook, this casserole guarantees big flavor with minimal effort. Make it once, and it just might become your go-to comfort food staple.

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